- U.S. Small Business Administration
- Union Community Church
- Union Township School Corporation
- United Methodist Church
- United States Postal Service
- United Urban Network, Inc.
- United Way Northwest Indiana
- United Way of La Porte County
- United Way Regional Volunteer Center
- UnitedHealthcare
- Unity Foundation of La Porte County
- University of Notre Dame
- University of Saint Francis
- Uptown Arts District
- Uptown East Apartments
- Urban League of Northwest Indiana
- Urschel Laboratories, Inc.
- US College Planning